painguy.com painguy.com - Pain Guy - Exploring What Works

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Title: Pain Guy - Exploring What Works
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Pain Guy - Exploring What Works Pain Guy Exploring What Works Home About Jonnie Contact Resources Pain Words Pacing Neuropathic Pain – New Treatment Hope? July 24, 2015 by Jonathan Blood Smyth Leave a Comment Researchers at Duke University in the United States have made a potentially very important discovery in the fight against neuropathic pain. In mice with neuropathic pain they injected bone marrow cells into the spinal cord area and found a significant reduction in their chronic pain for a relatively long period. Treatment of pain from neuropathy is limited and has not greatly changed for many years, with improvement from medication measured in hours rather than longer periods. The bottom line is that if a person has a chronic, neuropathic type pain, treatment options are limited. They have to suffer an unpleasant pain problem with poor relief and little change in their symptoms. A neurologist may confirm they have a peripheral neuropathy and prescribe medication or a TENS machine but they are unable to get at the cause of the problem. Pain management may be a useful way to manage chronic pain but does not greatly change the pain problem itself. Neuropathic pain is not well recognised or understood by the general public. However, anyone who has neuropathic pain knows very vividly what it’s all about. It can be severe, persistent and resistant to treatment, cutting badly into a person’s quality of life. What Is Neuropathic Pain? A Quick Definition The nervous system normally works as a transmitter of impulses generated in the tissues. In an ankle sprain for example, ligament tissues are damaged and the local nerves transmit pain up the nervous system to the brain where we can interpret what ‘s happened and take action as necessary. In neuropathic pain, due to damage, disease or injury the nervous system becomes a generator of pain itself. Changes occur in the structure and in the electrical and chemical behaviour of nerves. This occurs in nerves in the body, the nerve bundles near the spinal cord, in the spinal cord and in the brain itself. This means that treatment for a nerve pain in the ankle, back, neck or face will have a very limited effect as the problem is in the way the wiring is working. The nervous system lines have been rewired, a problem that drug treatment cannot reach. Neuropathic pain conditions include trigeminal neuralgia, complex regional pain syndrome, peripheral neuropathy and diabetic neuropathy amongst others. Phantom pain after amputation could also be included in this category. The Recent Research in Nerve Pain Researchers damaged the lower limb nerves of mice by tying ligatures around them or by cutting short pieces of the nerves out so they could not transmit any more. These techniques are known to cause the central nervous system to set up a severe pain reaction. They then removed a particular type of bone marrow cells from the mice, cells with the ability to develop into a variety of different cells. These cells are also able to suppress immune reactions in the nervous system. Bone marrow cells were injected into the spinal canal via lumbar puncture (on a mouse!). The results showed several weeks of suppression of neuropathic pain from both types of deliberate nerve injury. A chemical (transforming growth factor beta one or TGF-β1) was shown to be a powerful changer of the pain transmitting mechanisms. The pain relief started quickly, at around a day from the injection, and lasted for five weeks. Even if the pain was allowed to develop for 14 days before treatment, there was still a reduction in pain. The more cells that were injected the longer the period of pain relief. This research is very important, although I don’t pretend to understand the complex anatomy and biochemistry laid out in the paper. For the first time it is possible to greatly reduce neuropathic pain for a significant length of time. This holds out hope that we will be able to find effective treatments for a large number of people who must live every day with pain. Reference: Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion G Chen, CK Park, RG Xie, RR Ji – The Journal of clinical investigation, 2015 Image credit: On Flickr Album of neurollero Filed Under: Uncategorized Elbow pain – tendonitis update April 9, 2015 by Jonathan Blood Smyth Leave a Comment It’s been about five weeks since I started my regime of strengthening my forearm muscles and there has been progress. I’m not yet sure if it’s affected my tennis elbow pain but I’m only just starting. When I began squeezing the weaker of the two hand grippers I could do about seven proper closes, where the handles came together with an audible click to show I had fully closed them. Now I can easily do 12 closes and for three sets, using this to warm up my forearms before I move to the stronger set of grippers. I bought the .5 (point five) gripper which has a closing strength of 120 pounds but as my grip was very weak to start with I could not close it even half way. Well I still can’t close the .5 gripper all the way even once yet, but I’m getting closer and doing seven good reps for three sets after I have warmed up. My forearm then feels really pumped up and overall my grip feels stronger. So I’m continuing to use the strengthening, every other day, to see if it helps my tennis elbow pain tendonitis problem. If you’ve got any good ideas to help this troublesome and not easily treated problem please let me know. Filed Under: Uncategorized Tennis Elbow – Get A Grip Of Elbow Pain February 1, 2015 by Jonathan Blood Smyth Leave a Comment Getting a decent grip on things is the major issue with tennis elbow. Elbow pain is one of those annoying musculoskeletal problems that plague us as we get older and seem to just become part of who we are. As time goes on the list increases of all the things you’ve “got wrong with you” and if you remember back to when you were in your twenties you had none of them at all. When it’s acute it’s a real bitch. Ever had an acute tendonitis, the type which comes on strongly after you’ve overdone something? If you have you’ll remember it as I remember the pain in the extensor tendon of my right thumb. At night I held it up in the air because putting it down anywhere resulted in such severe pain. It was a day or so before I put it into a splint, rather an oversight for a physiotherapist who’s supposed to know how to manage these things. It did settle down completely because it was an “-itis”, an acute inflammation in response to high physical stresses. Most tennis elbow symptoms are much less acute and many episodes never have an initial, highly painful episode, just grumbling from the onset. What is Tennis Elbow? Tennis elbow is an overuse syndrome and perhaps the most common. This means we get tennis elbow because we do too much of one thing for too long. We’re designed to do a large variety of things not very often, not one thing a lot of times such as in repet...

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